The state of São Paulo boasts South America’s largest port, Santos, which in 2012 handled 105 million tons of cargo with a value of US$ 120 billion, or about one quarter of Brazil’s trade flow. With a total working area of 7.8 million m2 and with 13 kilometers of docks, the port has special terminals for grains, fertilizers, bulk liquids, vehicles and containers.

São Sebastião Port, which is also located in the state of São Paulo (200 km from the state capital) has a natural setting that places it as one of the best ports in the world, due to its depth. In 2012 it handled 878,000 tons of cargo at its public commercial wharf.

The ports of São Paulo also serve the states of Minas Gerais, Mato Grosso, Mato Grosso do Sul, Goiás, Paraná, Rio de Janeiro, as well as the countries of the MERCOSUR.

More info:
Department of Logistics and Transportation (link in Portuguese) 
Tunnel Santos-Guarujá (video)